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In this research, we propose a Multi-Filament Fused Deposit Modelling (MFFMD) printer and a respective generator that can be used to produce structural parts with locally tailored functional properties. 3D-printed structural components can highly benefit from multi-material printing with tuneable functional properties. Currently, multi-material printing is mainly achieved using multiple separate nozzles, leading to discontinuous flow in switching materials. This limitation results in material interface delamination, minimal control in the continuous transition of material properties, and longer production time.To address this, we first design and build an MFFMD printer with a single customized nozzle allowing seamless switching between multiple filaments. We then develop a method that generates a continuous toolpath of a given geometry and differentiates materials based on various stress conditions at particular regions. To illustrate, we fabricate a Pratt truss as an example of a tension-compression structure as a case study. In one go, the MFFMD printer deposits resistant filament, respectively, at tension- or compression-concentrated regions based on local stress conditions. Comparative load tests are conducted to validate the performance enhancement of multi-filament prints against single-filament prints. Our proposed method is a prototypical study conducted on a small scale. While it mainly uses thermal plastic filaments, it can be expanded to other construction materials and scales in the future.